Prognostic significance of hypoxia-inducible factor-1α expression in advanced pharyngeal cancer without human papillomavirus infection

Abstract Objective This study aimed to clarify the association between both hypoxia-inducible factor-1α and glucose transporter type-1 expression survival outcome in advanced pharyngeal cancer without human papillomavirus infection. Method Twenty-five oropharyngeal 55 hypopharyngeal patients infection were enrolled. All had stage III–IV lesions underwent concurrent chemoradiotherapy or surgery. Hypoxia-inducible investigated primary by immunohistochemistry. Results There 41 39 cases with low high expression, 28 52 respectively. was no significant correlation expression. In univariate analysis, nodal metastasis, clinical but not predicted significantly worse prognosis. multivariate overexpression correlated poor overall survival, disease-specific recurrence-free survival. Conclusion High an independent risk factor for prognosis papillomavirus-unrelated cancer.